How tumors make bad blood vessels and stroma
HF Dvorak - The American journal of pathology, 2003 - ASIP
Solid tumors are composed of two distinct but interdependent compartments: the malignant
cells themselves (parenchyma) and the supporting connective tissue (stroma) that they
induce and in which they are dispersed. 1, 2 The quantity of stroma is highly variable from
tumor to tumor but all solid tumors, regardless of type or cellular origin, require stroma for
nutrition and waste disposal if they are to grow beyond minimal size. 3 The discrete
separation of parenchymal cells from stroma is not unique to tumors. Normal tissues are also …
cells themselves (parenchyma) and the supporting connective tissue (stroma) that they
induce and in which they are dispersed. 1, 2 The quantity of stroma is highly variable from
tumor to tumor but all solid tumors, regardless of type or cellular origin, require stroma for
nutrition and waste disposal if they are to grow beyond minimal size. 3 The discrete
separation of parenchymal cells from stroma is not unique to tumors. Normal tissues are also …