MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion

J Bockhorn, K Yee, YF Chang, A Prat, D Huo… - Breast cancer research …, 2013 - Springer
J Bockhorn, K Yee, YF Chang, A Prat, D Huo, C Nwachukwu, R Dalton, S Huang…
Breast cancer research and treatment, 2013Springer
Metastasis remains a significant challenge in treating cancer. A better understanding of the
molecular mechanisms underlying metastasis is needed to develop more effective
treatments. Here, we show that human breast tumor biomarker miR-30c regulates invasion
by targeting the cytoskeleton network genes encoding twinfilin 1 (TWF1) and vimentin (VIM).
Both VIM and TWF1 have been shown to regulate epithelial-to-mesenchymal transition.
Similar to TWF1, VIM also regulates F-actin formation, a key component of cellular transition …
Abstract
Metastasis remains a significant challenge in treating cancer. A better understanding of the molecular mechanisms underlying metastasis is needed to develop more effective treatments. Here, we show that human breast tumor biomarker miR-30c regulates invasion by targeting the cytoskeleton network genes encoding twinfilin 1 (TWF1) and vimentin (VIM). Both VIM and TWF1 have been shown to regulate epithelial-to-mesenchymal transition. Similar to TWF1, VIM also regulates F-actin formation, a key component of cellular transition to a more invasive mesenchymal phenotype. To further characterize the role of the TWF1 pathway in breast cancer, we found that IL-11 is an important target of TWF1 that regulates breast cancer cell invasion and STAT3 phosphorylation. The miR-30c-VIM/TWF1 signaling cascade is also associated with clinical outcome in breast cancer patients.
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