[HTML][HTML] Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival
S Strack, JT Cribbs, L Gomez - Journal of Biological Chemistry, 2004 - ASBMB
The predominant forms of protein phosphatase 2A (PP2A), one of the major Ser/Thr
phosphatases, are dimers of catalytic (C) and scaffolding (A) subunits and trimers with an
additional variable regulatory subunit. In mammals, catalytic and scaffolding subunits are
encoded by two genes each (α/β), whereas three gene families (B, B′, and B ″) with a total
of 12 genes contribute PP2A regulatory subunits. We generated stable PC12 cell lines in
which the major scaffolding Aα subunit can be knocked down by inducible RNA interference …
phosphatases, are dimers of catalytic (C) and scaffolding (A) subunits and trimers with an
additional variable regulatory subunit. In mammals, catalytic and scaffolding subunits are
encoded by two genes each (α/β), whereas three gene families (B, B′, and B ″) with a total
of 12 genes contribute PP2A regulatory subunits. We generated stable PC12 cell lines in
which the major scaffolding Aα subunit can be knocked down by inducible RNA interference …