[PDF][PDF] PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

R Cao, MA Björndahl, P Religa, S Clasper, S Garvin… - Cancer cell, 2004 - cell.com
R Cao, MA Björndahl, P Religa, S Clasper, S Garvin, D Galter, B Meister, F Ikomi, K Tritsaris…
Cancer cell, 2004cell.com
Cancer metastases are commonly found in the lymphatic system. Like tumor blood
angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several
tumor-derived growth factors. Here we report that members of the PDGF family act as
lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility
of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of
lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor …
Abstract
Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors. Here we report that members of the PDGF family act as lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph nodes. These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis.
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