Signaling for cell death by Fas/APO1 occurs via a distinct region in its intracellular domain.
This region contains a conserved sequence motif, the death domain motif, that is also found
in the intracellular domains of the p55 tumor necrosis factor receptor and the low affinity
nerve growth factor receptor, as well as in the regulatory domain of the ankyrins. A novel
protein that specifically binds to the death domain of Fas/APO1 but not to Fas/APO1
molecules with a loss of function point mutation occurring in lpr cg mice was cloned by a two …