TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients
P Wu, J Wu, S Liu, X Han, J Lu, Y Shi, J Wang, L Lu… - Clinical …, 2008 - Elsevier
Plasmacytoid dendritic cells (pDCs) can produce a large amount of interferon-alpha (IFN-α)
upon exposure to TLR9 or TLR7 agonists. Human pDCs have been shown to play an
important role in the pathogenesis of systemic lupus erythematosus (SLE) through increased
production of IFN-α. So, how to negatively regulate activation of pDCs and how to evaluate
the activation of pDC in SLE patients attract much attention. BDCA2 is selectively expressed
on human pDCs, acting as a hallmark of human pDCs. In this study, we showed that BDCA2 …
upon exposure to TLR9 or TLR7 agonists. Human pDCs have been shown to play an
important role in the pathogenesis of systemic lupus erythematosus (SLE) through increased
production of IFN-α. So, how to negatively regulate activation of pDCs and how to evaluate
the activation of pDC in SLE patients attract much attention. BDCA2 is selectively expressed
on human pDCs, acting as a hallmark of human pDCs. In this study, we showed that BDCA2 …