Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a
I Bachelet, A Munitz, F Levi-Schaffer - Journal of allergy and clinical …, 2006 - Elsevier
BACKGROUND: Initiated and regulated by mast cells, allergic responses are balanced
through an intricate network of positive and negative signals. We have recently shown that
the inhibitory receptor CD300a is expressed on human mast cells and modulates a large
array of their functions. OBJECTIVE: We sought to evaluate CD300a as a negative regulator
of allergic inflammation in vivo by means of a bispecific antibody linking CD300a with IgE.
METHODS: Bispecific antibody fragments were generated by chemical conjugation of Fab …
through an intricate network of positive and negative signals. We have recently shown that
the inhibitory receptor CD300a is expressed on human mast cells and modulates a large
array of their functions. OBJECTIVE: We sought to evaluate CD300a as a negative regulator
of allergic inflammation in vivo by means of a bispecific antibody linking CD300a with IgE.
METHODS: Bispecific antibody fragments were generated by chemical conjugation of Fab …