Advances in understanding the role of type I interferons in systemic lupus erythematosus
MK Crow - Current opinion in rheumatology, 2014 - journals.lww.com
Current opinion in rheumatology, 2014•journals.lww.com
As demonstrated in the murine studies of persistent virus infection accompanied by
sustained production of IFN-I, blockade of the IFN-I pathway may reverse the immune
dysregulation and tissue damage that are the essential features of the immunopathogenesis
of SLE. Recent research progress has identified numerous therapeutic targets, and specific
candidate therapeutics relevant to the IFN-I pathway are under investigation.
sustained production of IFN-I, blockade of the IFN-I pathway may reverse the immune
dysregulation and tissue damage that are the essential features of the immunopathogenesis
of SLE. Recent research progress has identified numerous therapeutic targets, and specific
candidate therapeutics relevant to the IFN-I pathway are under investigation.
Summary
As demonstrated in the murine studies of persistent virus infection accompanied by sustained production of IFN-I, blockade of the IFN-I pathway may reverse the immune dysregulation and tissue damage that are the essential features of the immunopathogenesis of SLE. Recent research progress has identified numerous therapeutic targets, and specific candidate therapeutics relevant to the IFN-I pathway are under investigation.
Lippincott Williams & Wilkins