Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase
Y Zhong, EY Chen, R Liu, PY Chuang… - Journal of the …, 2013 - journals.lww.com
Abstract The Connectivity Map database contains microarray signatures of gene expression
derived from approximately 6000 experiments that examined the effects of approximately
1300 single drugs on several human cancer cell lines. We used these data to prioritize pairs
of drugs expected to reverse the changes in gene expression observed in the kidneys of a
mouse model of HIV-associated nephropathy (Tg26 mice). We predicted that the
combination of an angiotensin-converting enzyme (ACE) inhibitor and a histone deacetylase …
derived from approximately 6000 experiments that examined the effects of approximately
1300 single drugs on several human cancer cell lines. We used these data to prioritize pairs
of drugs expected to reverse the changes in gene expression observed in the kidneys of a
mouse model of HIV-associated nephropathy (Tg26 mice). We predicted that the
combination of an angiotensin-converting enzyme (ACE) inhibitor and a histone deacetylase …