Race, APOL1 risk, and eGFR decline in the general population
The APOL1 high-risk genotype, present in approximately 13% of blacks in the United States,
is a risk factor for kidney function decline in populations with CKD. It is unknown whether
genetic screening is indicated in the general population. We evaluated the prognosis of
APOL1 high-risk status in participants in the population-based Atherosclerosis Risk in
Communities (ARIC) study, including associations with eGFR decline, variability in eGFR
decline, and related adverse health events (AKI, ESRD, hypertension, diabetes …
is a risk factor for kidney function decline in populations with CKD. It is unknown whether
genetic screening is indicated in the general population. We evaluated the prognosis of
APOL1 high-risk status in participants in the population-based Atherosclerosis Risk in
Communities (ARIC) study, including associations with eGFR decline, variability in eGFR
decline, and related adverse health events (AKI, ESRD, hypertension, diabetes …
