[HTML][HTML] Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase
EA Nam, R Zhao, GG Glick, CE Bansbach… - Journal of Biological …, 2011 - ASBMB
The DNA damage response kinases ataxia telangiectasia-mutated (ATM), DNA-dependent
protein kinase (DNA-PK), and ataxia telangiectasia-mutated and Rad3-related (ATR) signal
through multiple pathways to promote genome maintenance. These related kinases share
similar methods of regulation, including recruitment to specific nucleic acid structures and
association with protein activators. ATM and DNA-PK also are regulated via
phosphorylation, which provides a convenient biomarker for their activity. Whether …
protein kinase (DNA-PK), and ataxia telangiectasia-mutated and Rad3-related (ATR) signal
through multiple pathways to promote genome maintenance. These related kinases share
similar methods of regulation, including recruitment to specific nucleic acid structures and
association with protein activators. ATM and DNA-PK also are regulated via
phosphorylation, which provides a convenient biomarker for their activity. Whether …