Mucosal immunity in HIV controllers: the right place at the right time
BL Shacklett, AL Ferre - Current Opinion in HIV and AIDS, 2011 - journals.lww.com
BL Shacklett, AL Ferre
Current Opinion in HIV and AIDS, 2011•journals.lww.comRecent findings suggest that MHC class I-restricted, CD8+ T cells are a major component of
immune control in 'elite controllers'. In addition, the presence of these effector cells at or near
critical viral reservoirs, such as mucosal tissues, may be critical in determining their
effectiveness at limiting viral replication and dissemination.
immune control in 'elite controllers'. In addition, the presence of these effector cells at or near
critical viral reservoirs, such as mucosal tissues, may be critical in determining their
effectiveness at limiting viral replication and dissemination.
Summary
Recent findings suggest that MHC class I-restricted, CD8+ T cells are a major component of immune control in ‘elite controllers’. In addition, the presence of these effector cells at or near critical viral reservoirs, such as mucosal tissues, may be critical in determining their effectiveness at limiting viral replication and dissemination.
Lippincott Williams & Wilkins