Sphingolipids (SFs) represent a large class of lipids playing diverse functions in a vast
number of physiological and pathological processes. Sphingomyelin (SM) is the most
abundant SF in the cell, with ubiquitous distribution within mammalian tissues, and
particularly high levels in the Central Nervous System (CNS). SM is an essential element of
plasma membrane (PM) and its levels are crucial for the cell function. SM content in a cell is
strictly regulated by the enzymes of SM metabolic pathways, which activities create a …