Case report: stimulation of the right amygdala induces transient changes in affective bias
Brain stimulation, 2014•Elsevier
Background Sensitive outcome measures are needed to quantify the effects of
neuromodulation in mood disorders. Objective This study examined the utility of a novel
affective bias (AB) task in identifying transient mood changes induced by amygdala
stimulation in a single rare participant. Methods Localized, pulsed electrical stimulation was
delivered for 8 min during measures of AB and self-reported mood. Responses were
compared with those gathered without stimulation on the same day in the same setting …
neuromodulation in mood disorders. Objective This study examined the utility of a novel
affective bias (AB) task in identifying transient mood changes induced by amygdala
stimulation in a single rare participant. Methods Localized, pulsed electrical stimulation was
delivered for 8 min during measures of AB and self-reported mood. Responses were
compared with those gathered without stimulation on the same day in the same setting …
Background
Sensitive outcome measures are needed to quantify the effects of neuromodulation in mood disorders.
Objective
This study examined the utility of a novel affective bias (AB) task in identifying transient mood changes induced by amygdala stimulation in a single rare participant.
Methods
Localized, pulsed electrical stimulation was delivered for 8 min during measures of AB and self-reported mood. Responses were compared with those gathered without stimulation on the same day in the same setting, using paired t-tests.
Results
Stimulation of the basolateral nucleus of the right amygdala at 50 Hz, 15 V, and 200 μs pulse-width produced a significant positive shift in AB (t = −2.864, df = 53, P = .006), despite equivocal findings on self-reported mood (t = −.184, df = 12, P = .857).
Conclusion
Affective bias may be more sensitive to stimulation-induced fluctuations in mood than subjective report, suggesting utility as an outcome measure in neuromodulation studies.
Elsevier