[HTML][HTML] Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis
N Irie, Y Takada, Y Watanabe, Y Matsuzaki… - Journal of Biological …, 2009 - ASBMB
Bone is remodeled constantly throughout life by bone-resorbing osteoclasts and bone-
forming osteoblasts. To maintain bone volume and quality, differentiation of osteoclasts and
osteoblasts is tightly regulated through communication between and within these two cell
lineages. Previously we reported that cell-cell interaction mediated by ephrinB2 ligand on
osteoclasts and EphB4 receptor on osteoblasts generates bidirectional anti-
osteoclastogenic and pro-osteoblastogenic signals into respective cells and presumably …
forming osteoblasts. To maintain bone volume and quality, differentiation of osteoclasts and
osteoblasts is tightly regulated through communication between and within these two cell
lineages. Previously we reported that cell-cell interaction mediated by ephrinB2 ligand on
osteoclasts and EphB4 receptor on osteoblasts generates bidirectional anti-
osteoclastogenic and pro-osteoblastogenic signals into respective cells and presumably …