Integrins in angiogenesis and lymphangiogenesis

CJ Avraamides, B Garmy-Susini, JA Varner - Nature Reviews Cancer, 2008 - nature.com
CJ Avraamides, B Garmy-Susini, JA Varner
Nature Reviews Cancer, 2008nature.com
Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate
tumour metastasis by serving as conduits for the transport of tumour cells to new sites.
Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a
family of cell surface receptors whose ligands are extracellular matrix proteins and
immunoglobulin superfamily molecules. Select integrins promote endothelial cell migration
and survival during angiogenesis and lymphangiogenesis, whereas other integrins promote …
Abstract
Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate tumour metastasis by serving as conduits for the transport of tumour cells to new sites. Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and immunoglobulin superfamily molecules. Select integrins promote endothelial cell migration and survival during angiogenesis and lymphangiogenesis, whereas other integrins promote pro-angiogenic macrophage trafficking to tumours. Several integrin-targeted therapeutic agents are currently in clinical trials for cancer therapy. Here, we review the evidence implicating integrins as a family of fundamental regulators of angiogenesis and lymphangiogenesis.
nature.com