[HTML][HTML] Bcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer
MH Lawson, NM Cummings, DM Rassl… - British journal of …, 2010 - nature.com
MH Lawson, NM Cummings, DM Rassl, SL Vowler, M Wickens, WJ Howat, JD Brenton…
British journal of cancer, 2010•nature.comMethods: A TMA was constructed consisting of 184 cases of SCLC and stained for
expression of Bcl-2 and β 1-integrin. The slides were scored and the role of the proteins in
survival was determined using Cox regression analysis. A meta-analysis of the role of Bcl-2
expression in SCLC prognosis was performed based on published results. Results: Both
proteins were expressed at high levels in the SCLC cases. For Bcl-2 (n= 140), the hazard
ratio for death if the staining was weak in intensity was 0.55 (0.33–0.94, P= 0.03) and for β 1 …
expression of Bcl-2 and β 1-integrin. The slides were scored and the role of the proteins in
survival was determined using Cox regression analysis. A meta-analysis of the role of Bcl-2
expression in SCLC prognosis was performed based on published results. Results: Both
proteins were expressed at high levels in the SCLC cases. For Bcl-2 (n= 140), the hazard
ratio for death if the staining was weak in intensity was 0.55 (0.33–0.94, P= 0.03) and for β 1 …
Methods:
A TMA was constructed consisting of 184 cases of SCLC and stained for expression of Bcl-2 and β 1-integrin. The slides were scored and the role of the proteins in survival was determined using Cox regression analysis. A meta-analysis of the role of Bcl-2 expression in SCLC prognosis was performed based on published results.
Results:
Both proteins were expressed at high levels in the SCLC cases. For Bcl-2 (n= 140), the hazard ratio for death if the staining was weak in intensity was 0.55 (0.33–0.94, P= 0.03) and for β 1-integrin (n= 151) was 0.60 (0.39–0.92, P= 0.02). The meta-analysis showed an overall hazard ratio for low expression of Bcl-2 of 0.91 (0.74–1.09).
Conclusions:
Both Bcl-2 and β 1-integrin are independent prognostic factors in SCLC in this cohort although further validation is required to confirm their importance. A TMA of SCLC cases is feasible but challenging and an important tool for biomarker validation.
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