Dual inhibition of αV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer
J Jia, A Starodub, I Cushman, Y Liu, DJ Marshall… - Anti-cancer …, 2013 - journals.lww.com
Both Src and α V integrins are important for tumor growth and angiogenesis. They are
interconnected and responsible for important features of the tumor phenotype including
invasiveness, metastasis, angiogenesis, and resistance to apoptosis. This study examines
whether combinational inhibition of both integrin and Src pathways would exert greater
antiangiogenesis and antitumor effects than either pathway alone. Using in-vitro cell culture
systems, the activity of CNTO95 (Intetumumab), an α V integrin inhibitor, and dasatinib, an …
interconnected and responsible for important features of the tumor phenotype including
invasiveness, metastasis, angiogenesis, and resistance to apoptosis. This study examines
whether combinational inhibition of both integrin and Src pathways would exert greater
antiangiogenesis and antitumor effects than either pathway alone. Using in-vitro cell culture
systems, the activity of CNTO95 (Intetumumab), an α V integrin inhibitor, and dasatinib, an …