Thrombotic microangiopathy as a cause of chronic kidney transplant dysfunction: case report demonstrating successful treatment with eculizumab

Z Iqbal, K Wood, V Carter, TH Goodship… - Transplantation …, 2015 - Elsevier
Atypical hemolytic uremic syndrome is a rare disease associated with genetic or acquired
defects in complement regulation which frequently leads to renal failure. Disease often
recurs early after kidney transplantation, leading to a rapid irreversible loss of function.
Extrarenal features, such as hemolysis and thrombocytopenia, may not always occur, and
diagnosis is made by demonstrating the classic features of thrombotic microangiopathy on
renal biopsy. Eculizumab, a terminal complement inhibitor, has been used successfully to …