[HTML][HTML] Atypical hemolytic uremic syndrome: telling the difference between H and Y

EG De Jorge, MC Pickering - Kidney international, 2010 - Elsevier
Kidney international, 2010Elsevier
Mutations in the complement factor H (CFH) gene are frequently associated with atypical
hemolytic uremic syndrome (aHUS). Hakobyan et al. have developed novel reagents that
can rapidly determine the contribution of each CFH allele to the total plasma CFH pool,
showing that low-expression CFH alleles are important risk factors for the development of
aHUS. These reagents represent a significant contribution to the techniques used to
determine susceptibility factors among individuals with aHUS.
Mutations in the complement factor H (CFH) gene are frequently associated with atypical hemolytic uremic syndrome (aHUS). Hakobyan et al. have developed novel reagents that can rapidly determine the contribution of each CFH allele to the total plasma CFH pool, showing that low-expression CFH alleles are important risk factors for the development of aHUS. These reagents represent a significant contribution to the techniques used to determine susceptibility factors among individuals with aHUS.
Elsevier