Jurassic PARK2: you eat your mitochondria, and you are what your mitochondria eat
GW Dorn - Autophagy, 2016 - Taylor & Francis
GW Dorn
Autophagy, 2016•Taylor & FrancisPark2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial
quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized
mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer
carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our
findings demonstrate how functional interactions between mitophagic mitochondrial removal
and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.
quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized
mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer
carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our
findings demonstrate how functional interactions between mitophagic mitochondrial removal
and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.
Abstract
Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.
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