[HTML][HTML] HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model
E Saba, JC Grivel, C Vanpouille, B Brichacek… - Mucosal …, 2010 - Elsevier
Infection and dissemination of human immunodeficiency virus (HIV)-1 through the female
body after vaginal intercourse depends on the activation/differentiation status of mucosal
CD4 T cells. In this study, we investigated this status and the susceptibility to HIV-1 infection
of human cervico-vaginal tissue ex vivo. We found that virtually all T cells are of the effector
memory phenotype with broad CC chemokine receptor 5 (CCR5) expression. As it does in
vivo, human cervico-vaginal tissue ex vivo preferentially supports the productive infection of …
body after vaginal intercourse depends on the activation/differentiation status of mucosal
CD4 T cells. In this study, we investigated this status and the susceptibility to HIV-1 infection
of human cervico-vaginal tissue ex vivo. We found that virtually all T cells are of the effector
memory phenotype with broad CC chemokine receptor 5 (CCR5) expression. As it does in
vivo, human cervico-vaginal tissue ex vivo preferentially supports the productive infection of …