In Vitro Assessment of the Immunological Significance of a Human Monoclonal Antibody Directed to the Influenza A Virus Nucleoprotein
R Bodewes, MM Geelhoed-Mieras… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
Clinical and Vaccine Immunology, 2013•Am Soc Microbiol
Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies
directed to the conserved viral nucleoprotein (NP) may play a role in immunity against
various influenza A virus subtypes. Here, we assessed the immunological significance of a
human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected
cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity,
or opsonization of viral antigen for improved antigen presentation to CD8+ T cells by …
directed to the conserved viral nucleoprotein (NP) may play a role in immunity against
various influenza A virus subtypes. Here, we assessed the immunological significance of a
human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected
cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity,
or opsonization of viral antigen for improved antigen presentation to CD8+ T cells by …
Abstract
Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity, or opsonization of viral antigen for improved antigen presentation to CD8+ T cells by dendritic cells.
American Society for Microbiology