[PDF][PDF] Regulation of DNA damage responses by ubiquitin and SUMO

SP Jackson, D Durocher - Molecular cell, 2013 - cell.com
Molecular cell, 2013cell.com
Ubiquitylation and sumoylation, the covalent attachment of the polypeptides ubiquitin and
SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular
functions. Here, we summarize the key steps and enzymes involved in ubiquitin and SUMO
conjugation and provide an overview of how they are crucial for maintaining genome
stability. Specifically, we review research that has revealed how ubiquitylation and
sumoylation regulate and coordinate various pathways of DNA damage recognition …
Ubiquitylation and sumoylation, the covalent attachment of the polypeptides ubiquitin and SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular functions. Here, we summarize the key steps and enzymes involved in ubiquitin and SUMO conjugation and provide an overview of how they are crucial for maintaining genome stability. Specifically, we review research that has revealed how ubiquitylation and sumoylation regulate and coordinate various pathways of DNA damage recognition, signaling, and repair at the biochemical, cellular, and whole-organism levels. In addition to providing key insights into the control and importance of DNA repair and associated processes, such work has established paradigms for regulatory control that are likely to extend to other cellular processes and that may provide opportunities for better understanding and treatment of human disease.
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