Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair …
G Iliakis, T Murmann, A Soni - Mutation Research/Genetic Toxicology and …, 2015 - Elsevier
DNA double strand breaks (DSB) are the most deleterious lesions for the integrity of the
genome, as their misrepair can lead to the formation of chromosome translocations. Cells
have evolved two main repair pathways to suppress the formation of these genotoxic
lesions: homology-dependent, error-free homologous recombination repair (HRR), and
potentially error-prone, classical, DNA-PK-dependent non-homologous end-joining (c-
NHEJ). The most salient feature of c-NHEJ, speed, will largely suppress chromosome …
genome, as their misrepair can lead to the formation of chromosome translocations. Cells
have evolved two main repair pathways to suppress the formation of these genotoxic
lesions: homology-dependent, error-free homologous recombination repair (HRR), and
potentially error-prone, classical, DNA-PK-dependent non-homologous end-joining (c-
NHEJ). The most salient feature of c-NHEJ, speed, will largely suppress chromosome …