The biological basis for conformal three-dimensional radiation therapy

SA Leibel, CC Ling, GJ Kutcher, R Mohan… - International Journal of …, 1991 - Elsevier
The recent introduction of new computer technology for treatment planning and computer-
driven treatment delivery systems, such as multi-leaf collimators and on-line verification
systems, has accelerated the development of 3-dimensional (3-D) radiation therapy as a
modality for curative cancer treatment. The goal of 3-D treatment planning is to conform the
spatial distribution of the high radiation dose to the shape of the tumor contour while
concomitantly decreasing the volume of the surrounding normal tissues receiving high …