[HTML][HTML] IL-4/IL-13 signaling beyond Jak/Stat
H Jiang, MB Harris, P Rothman - Journal of Allergy and Clinical …, 2000 - Elsevier
In the past several years, extensive studies on the mechanisms underlying IL-4 and IL-13
signaling have enabled us to gain insight into how these cytokines regulate immune
responses. Because both IL-4 and IL-13 use the IL-4Rα as a receptor component, these
cytokines activate many common signaling pathways. Both of these cytokines use Janus
kinases (JAKs) to initiate signaling and activate signal transducer and activator of
transcription-6 (STAT6), which is a transcription factor required for many of their biologic …
signaling have enabled us to gain insight into how these cytokines regulate immune
responses. Because both IL-4 and IL-13 use the IL-4Rα as a receptor component, these
cytokines activate many common signaling pathways. Both of these cytokines use Janus
kinases (JAKs) to initiate signaling and activate signal transducer and activator of
transcription-6 (STAT6), which is a transcription factor required for many of their biologic …