Hsp90 in cancer: transcriptional roles in the nucleus
SK Calderwood, L Neckers - Advances in cancer research, 2016 - Elsevier
Hsp90 plays a key role in fostering metabolic pathways essential in tumorigenesis through
its functions as a molecular chaperone. Multiple oncogenic factors in the membrane and
cytoplasm are thus protected from degradation and destruction. Here, we have considered
Hsp90's role in transcription in the nucleus. Hsp90 functions both in regulating the activity of
sequence-specific transcription factors such as nuclear receptors and HSF1, as well as
impacting more globally acting factors that act on chromatin and RNA polymerase II. Hsp90 …
its functions as a molecular chaperone. Multiple oncogenic factors in the membrane and
cytoplasm are thus protected from degradation and destruction. Here, we have considered
Hsp90's role in transcription in the nucleus. Hsp90 functions both in regulating the activity of
sequence-specific transcription factors such as nuclear receptors and HSF1, as well as
impacting more globally acting factors that act on chromatin and RNA polymerase II. Hsp90 …