Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers
J Overgaard, MR Horsman - Seminars in radiation oncology, 1996 - Elsevier
It is now well established that most animal solid tumors contain oxygen-deficient hypoxic
cells and that these cells will influence the response of those tumors to radiation. Identifying
hypoxic cells in human tumors has proven more difficult, primarily because most of the direct
procedures used in animals are not applicable to humans. However, substantial indirect
evidence, which goes back to as early as 1909, clearly indicates the presence of hypoxia in
human tumors, although with a considerable heterogeneity among individual tumors …
cells and that these cells will influence the response of those tumors to radiation. Identifying
hypoxic cells in human tumors has proven more difficult, primarily because most of the direct
procedures used in animals are not applicable to humans. However, substantial indirect
evidence, which goes back to as early as 1909, clearly indicates the presence of hypoxia in
human tumors, although with a considerable heterogeneity among individual tumors …