[HTML][HTML] Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene
M Meissner, P Weissgerber, JEC Londono… - Journal of Biological …, 2011 - ASBMB
The major L-type voltage-gated calcium channels in heart consist of an α1C (Ca V 1.2)
subunit usually associated with an auxiliary β subunit (Ca V β2). In embryonic
cardiomyocytes, both the complete and the cardiac myocyte-specific null mutant of Ca V β2
resulted in reduction of L-type calcium currents by up to 75%, compromising heart function
and causing defective remodeling of intra-and extra-embryonic blood vessels followed by
embryonic death. Here we conditionally excised the Ca V β2 gene (cacnb2) specifically in …
subunit usually associated with an auxiliary β subunit (Ca V β2). In embryonic
cardiomyocytes, both the complete and the cardiac myocyte-specific null mutant of Ca V β2
resulted in reduction of L-type calcium currents by up to 75%, compromising heart function
and causing defective remodeling of intra-and extra-embryonic blood vessels followed by
embryonic death. Here we conditionally excised the Ca V β2 gene (cacnb2) specifically in …