[HTML][HTML] Roles of a Membrane-localized βSubunit in the Formation and Targeting of Functional L-type Ca2+ Channels (∗)

AJ Chien, X Zhao, RE Shirokov, TS Puri… - Journal of Biological …, 1995 - ASBMB
We report several unexpected findings that provide novel insights into the properties and
interactions of the α 1 and β subunits of dihydropyridine-sensitive L-type channels. First, the
β 2a subunit was expressed as multiple species of 68-72 kDa; the 70-72-kDa species arose
from post-translational modification. Second, cell fractionation and immunocytochemical
studies indicated that the hydrophilic β 2a subunit, when expressed alone, was membrane-
localized. Third, the β 2a subunit increased the membrane localization of the α 1 subunit and …