Bronchiolitis obliterans syndrome (BOS) is a condition of progressive airflow obstruction that
affects a majority of lung transplant recipients and limits long-term posttransplant survival.
Although epithelial injury appears central to the development of BOS, little is known
regarding the specific epithelial cell types that are affected in this condition. We
hypothesized that BOS would involve preferential injury to the secretory Clara cells that
function in innate defense and epithelial repair. To test this hypothesis, we assessed tissue …