Androgen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer

ES Antonarakis, C Lu, B Luber, H Wang, Y Chen… - JAMA …, 2015 - jamanetwork.com
Importance We previously showed that detection of androgen receptor splice variant 7 (AR-
V7) in circulating tumor cells (CTCs) from men with castration-resistant prostate cancer
(CRPC) was associated with primary resistance to enzalutamide and abiraterone therapy,
but the relevance of AR-V7 status in the context of chemotherapy is unknown. Objective To
investigate whether AR-V7–positive patients would retain sensitivity to taxane chemotherapy
and whether AR-V7 status would have a differential impact on taxane-treated men …