[HTML][HTML] Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors
F Sun, H Chen, W Li, X Yang, X Wang, R Jiang… - Journal of Biological …, 2014 - ASBMB
Deregulation of androgen receptor (AR) splice variants has been implicated to play a role in
prostate cancer development and progression. To understand their functions in prostate, we
established a transgenic mouse model (AR3Tg) with targeted expression of the
constitutively active and androgen-independent AR splice variant AR3 (aka AR-V7) in
prostate epithelium. We found that overexpression of AR3 modulates expression of a
number of tumor-promoting autocrine/paracrine growth factors (including Tgfβ2 and Igf1) …
prostate cancer development and progression. To understand their functions in prostate, we
established a transgenic mouse model (AR3Tg) with targeted expression of the
constitutively active and androgen-independent AR splice variant AR3 (aka AR-V7) in
prostate epithelium. We found that overexpression of AR3 modulates expression of a
number of tumor-promoting autocrine/paracrine growth factors (including Tgfβ2 and Igf1) …