Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is considered an auto‐immune disorder. We evaluated expression of pSTAT1, T‐bet, and pSTAT3 in circulating T‐cells, B‐cells, and monocytes and spontaneous production of interleukin‐17 (IL17), interferon‐gamma (IFNγ), and interleukin‐10 (IL10) by peripheral blood mononuclear cells (PBMCs) from 14 active CIDP patients compared with 6 patients with long‐lasting remission and 20 controls. Active disease patients showed higher pSTAT1, T‐bet, and pSTAT3 in CD4⁺ T‐cells than controls (p < 0.001, p = 0.0002, p = 0.0097, respectively) and remission patients (p < 0.001, p = 0.0036, p = 0.0008, respectively). pSTAT1, T‐bet, and pSTAT3 were also higher in monocytes from active CIDP patients than controls (p = 0.0011, p = 0.0041, p = 0.0413, respectively) and remission patients (p = 0.0073, p = 0.0274, p = 0.0251, respectively). Moreover in CD8⁺ T‐cells, pSTAT3 expression was higher in active CIDP patients than in remission patients (p = 0.0345) and in controls (p = 0.0023). IL17 and IFNγ production were significantly higher in active CIDP patients than in controls (p < 0.0395, p = 0.0010, respectively); IFNγ levels were higher also in remission CIDP patients (p = 0.0073). IL10 levels were higher in active phase patients than in controls (p = 0.0334). Our data suggest that pSTAT1, T‐bet, and pSTAT3 can be considered putative markers of disease activity and potential targets for specific therapies.