[HTML][HTML] Protein kinase C (PKC) ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts

C García-Hoz, G Sánchez-Fernández… - Journal of Biological …, 2012 - ASBMB
Gq-coupled G protein-coupled receptors (GPCRs) mediate the actions of a variety of
messengers that are key regulators of cardiovascular function. Enhanced Gα q-mediated
signaling plays an important role in cardiac hypertrophy and in the transition to heart failure.
We have recently described that Gα q acts as an adaptor protein that facilitates PKCζ-
mediated activation of ERK5 in epithelial cells. Because the ERK5 cascade is known to be
involved in cardiac hypertrophy, we have investigated the potential relevance of this …