[PDF][PDF] Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway

D Mao, X Wu, C Deppong, LD Friend, G Dolecki… - Immunity, 2003 - cell.com
D Mao, X Wu, C Deppong, LD Friend, G Dolecki, DM Nelson, H Molina
Immunity, 2003cell.com
Factors involved in pregnancy failure due to abnormal fetomaternal tolerance are poorly
understood. Here we describe distinct defects in placenta formation and subsequent
pregnancy loss solely dependent on the activation of the complement alternative pathway
and the effector mechanisms provided by the maternal C3. Surprisingly, this effect is
independent of other complement activation pathways and of the effector mechanisms
provided by other complement components. These findings provide significant insight into …
Abstract
Factors involved in pregnancy failure due to abnormal fetomaternal tolerance are poorly understood. Here we describe distinct defects in placenta formation and subsequent pregnancy loss solely dependent on the activation of the complement alternative pathway and the effector mechanisms provided by the maternal C3. Surprisingly, this effect is independent of other complement activation pathways and of the effector mechanisms provided by other complement components. These findings provide significant insight into the role of the innate immune system in human pregnancy failure, a frequent clinical outcome.
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