Dysregulated complement activation as a common pathway of injury in preeclampsia and other pregnancy complications

AM Lynch, JE Salmon - Placenta, 2010 - Elsevier
The complement system protects the host against invading organisms, initiates inflammation
and dispose of immune complexes and the products of inflammatory injury. The complement
system provides an important link between the innate and adaptive immune systems.
Experimental observations suggest that increased complement activation causes and/or
perpetuates inflammation during pregnancy. Recent studies suggest a link between
complement activation and preeclampsia. Excessive activation or insufficient regulation of …