[HTML][HTML] Determinants of trophoblast lineage and cell subtype specification in the mouse placenta

DG Simmons, JC Cross - Developmental biology, 2005 - Elsevier
Developmental biology, 2005Elsevier
Cells of the trophoblast lineage make up the epithelial compartment of the placenta, and
their rapid development is essential for the establishment and maintenance of pregnancy. A
diverse array of specialized trophoblast subtypes form throughout gestation and are
responsible for mediating implantation, as well as promotion of blood to the implantation
site, changes in maternal physiology, and nutrient and gas exchange between the fetal and
maternal blood supplies. Within the last decade, targeted mutations in mice and the study of …
Cells of the trophoblast lineage make up the epithelial compartment of the placenta, and their rapid development is essential for the establishment and maintenance of pregnancy. A diverse array of specialized trophoblast subtypes form throughout gestation and are responsible for mediating implantation, as well as promotion of blood to the implantation site, changes in maternal physiology, and nutrient and gas exchange between the fetal and maternal blood supplies. Within the last decade, targeted mutations in mice and the study of trophoblast stem cells in vitro have contributed greatly to our understanding of trophoblast lineage development. Here, we review recent insights into the molecular pathways regulating trophoblast lineage segregation, stem cell maintenance, and subtype differentiation.
Elsevier