Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen.
J Decombaz, O Deriaz, K Acheson… - Medicine and science …, 1993 - europepmc.org
J Decombaz, O Deriaz, K Acheson, B Gmuender, E Jequier
Medicine and science in sports and exercise, 1993•europepmc.orgThe effect of L-carnitine on energy metabolism at a high lipolytic flux was studied. Nine
healthy male subjects received L-carnitine (CARN)(3 gd-1) for 7 d, or a placebo (CONT),
both with Ca pentothenate. The treatment increased resting nitrogen excretion slightly (+
15%, P< 0.02). After an overnight fast, the subjects were submitted successively to 20 min
bicycle exercise at 43+/-2 (SEM)% VO2max, a glycogen depletion routine involving high
intensity bouts to exhaustion, 1-2 h of rest, again 20 min at the initial load, and finally 20 min …
healthy male subjects received L-carnitine (CARN)(3 gd-1) for 7 d, or a placebo (CONT),
both with Ca pentothenate. The treatment increased resting nitrogen excretion slightly (+
15%, P< 0.02). After an overnight fast, the subjects were submitted successively to 20 min
bicycle exercise at 43+/-2 (SEM)% VO2max, a glycogen depletion routine involving high
intensity bouts to exhaustion, 1-2 h of rest, again 20 min at the initial load, and finally 20 min …
The effect of L-carnitine on energy metabolism at a high lipolytic flux was studied. Nine healthy male subjects received L-carnitine (CARN)(3 gd-1) for 7 d, or a placebo (CONT), both with Ca pentothenate. The treatment increased resting nitrogen excretion slightly (+ 15%, P< 0.02). After an overnight fast, the subjects were submitted successively to 20 min bicycle exercise at 43+/-2 (SEM)% VO2max, a glycogen depletion routine involving high intensity bouts to exhaustion, 1-2 h of rest, again 20 min at the initial load, and finally 20 min at 57+/-3% VO2max. After glycogen depletion, blood short-chain acylcarnitine concentrations increased 5 times as much in CARN as in CONT (P< 0.02). Fat oxidation estimated from respiratory gas exchange doubled after glycogen depletion for the same exercise intensity. However, there were no treatment differences in nonprotein RQ, heart rate, perceived fatigue, and blood parameters. It is concluded that during submaximal exercise after glycogen depletion (ie, at a high lipid flux) substrate metabolism is not influenced by L-carnitine supplementation.
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