[HTML][HTML] Transmission of atherosclerosis susceptibility with gut microbial transplantation

JC Gregory, JA Buffa, E Org, Z Wang… - Journal of Biological …, 2015 - ASBMB
Recent studies indicate both clinical and mechanistic links between atherosclerotic heart
disease and intestinal microbial metabolism of certain dietary nutrients producing
trimethylamine N-oxide (TMAO). Here we test the hypothesis that gut microbial
transplantation can transmit choline diet-induced TMAO production and atherosclerosis
susceptibility. First, a strong association was noted between atherosclerotic plaque and
plasma TMAO levels in a mouse diversity panel (n= 22 strains, r= 0.38; p= 0.0001). An …