Erythropoiesis is a coordinated process by which RBCs are produced. Erythropoietin, a
kidney-derived hormone, and iron are critical for the production of oxygen-carrying mature
RBCs. To meet the high demands of iron during erythropoiesis, small intestinal iron
absorption is increased through an undefined mechanism. In this study, erythropoietic
induction of iron absorption was further investigated. Hypoxia-inducible factor-2α (HIF-2α)
signaling was activated in the small intestine during erythropoiesis. Genetic disruption of HIF …