[HTML][HTML] Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking
DS Haines, JE Lee, SL Beauparlant, DB Kyle… - Molecular & Cellular …, 2012 - ASBMB
UBXD1 is a member of the poorly understood subfamily of p97 adaptors that do not harbor a
ubiquitin association domain or bind ubiquitin-modified proteins. Of clinical importance, p97
mutants found in familial neurodegenerative conditions Inclusion Body Myopathy Paget's
disease of the bone and/or Frontotemporal Dementia and Amyotrophic Lateral Sclerosis are
defective at interacting with UBXD1, indicating that functions regulated by a p97-UBXD1
complex are altered in these diseases. We have performed liquid chromatography-mass …
ubiquitin association domain or bind ubiquitin-modified proteins. Of clinical importance, p97
mutants found in familial neurodegenerative conditions Inclusion Body Myopathy Paget's
disease of the bone and/or Frontotemporal Dementia and Amyotrophic Lateral Sclerosis are
defective at interacting with UBXD1, indicating that functions regulated by a p97-UBXD1
complex are altered in these diseases. We have performed liquid chromatography-mass …