[HTML][HTML] Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis

JP Kennelly, JN van der Veen, RC Nelson… - Journal of Lipid …, 2018 - ASBMB
De novo phosphatidylcholine (PC) synthesis via CTP: phosphocholine cytidylyltransferase-α
(CTα) is required for VLDL secretion. To determine the precise role of de novo PC synthesis
in intestinal lipid metabolism, we deleted CTα exclusively in the intestinal epithelium of mice
(CTα IKO mice). When fed a chow diet, CTα IKO mice showed normal fat absorption despite
a∼ 30% decrease in intestinal PC concentrations relative to control mice, suggesting that
biliary PC can fully support chylomicron secretion under these conditions. However, when …