Members of the lipin protein family are phosphatidate phosphatase (PAP) enzymes, which
catalyze the dephosphorylation of phosphatidic acid to diacylglycerol, the penultimate step
in TAG synthesis. Lipins are unique among the glycerolipid biosynthetic enzymes in that
they also promote fatty acid oxidation through their activity as co-regulators of gene
expression by DNA-bound transcription factors. Lipin function has been evolutionarily
conserved from a single ortholog in yeast to the mammalian family of three lipin proteins …