Sputum phagocytes from healthy individuals are functional and activated: a flow cytometric comparison with cells in bronchoalveolar lavage and peripheral blood
N Alexis, J Soukup, A Ghio, S Becker - Clinical immunology, 2000 - Elsevier
Cells in the bronchial airways of healthy individuals are continuously exposed to inhaled
particulates in the size range 2–5 μm, which preferentially deposit in the bronchial rather
than the alveolar lung. Induced sputum obtains cells primarily from the surfaces of bronchial
airways. Using flow cytometry, we investigated whether sputum phagocytes demonstrate
phenotypes indicative of increased functional activation and inflammation compared to
phagocytes from the alveolar airways and peripheral blood (PB) in healthy subjects (N= 17) …
particulates in the size range 2–5 μm, which preferentially deposit in the bronchial rather
than the alveolar lung. Induced sputum obtains cells primarily from the surfaces of bronchial
airways. Using flow cytometry, we investigated whether sputum phagocytes demonstrate
phenotypes indicative of increased functional activation and inflammation compared to
phagocytes from the alveolar airways and peripheral blood (PB) in healthy subjects (N= 17) …