IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis
JG Krueger, S Fretzin, M Suárez-Fariñas… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: In subjects with psoriasis, inflammation and epidermal hyperplasia are
thought to be controlled by T cell–derived cytokines. Evidence suggests that the TH17 cell
cytokine IL-17A (IL-17) might play a role in disease pathogenesis. OBJECTIVE: We sought
to understand the effect that neutralization of IL-17 has on the clinical features of psoriasis
and to understand the role that IL-17 has in inflammatory pathways underlying psoriasis in
human subjects. METHODS: We examined skin lesions obtained from 40 subjects …
thought to be controlled by T cell–derived cytokines. Evidence suggests that the TH17 cell
cytokine IL-17A (IL-17) might play a role in disease pathogenesis. OBJECTIVE: We sought
to understand the effect that neutralization of IL-17 has on the clinical features of psoriasis
and to understand the role that IL-17 has in inflammatory pathways underlying psoriasis in
human subjects. METHODS: We examined skin lesions obtained from 40 subjects …