[HTML][HTML] Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD

C Doe, M Bafadhel, S Siddiqui, D Desai, V Mistry… - Chest, 2010 - Elsevier
Background Asthma and COPD are characterized by airway dysfunction and inflammation.
Neutrophilic airway inflammation is a common feature of COPD and is recognized in
asthma, particularly in severe disease. The T helper (Th) 17 cytokines IL-17A and IL-17F
have been implicated in the development of neutrophilic airway inflammation, but their
expression in asthma and COPD is uncertain. Methods We assessed IL-17A and IL-17F
expression in the bronchial submucosa from 30 subjects with asthma, 10 ex-smokers with …