Identification of cells expressing IL-17A and IL-17F in the lungs of patients with COPD
A Eustace, LJC Smyth, L Mitchell, K Williamson… - Chest, 2011 - Elsevier
Background Lymphocytes secrete IL-17A and IL-17F, which enhance innate immune
responses. IL-17 expression has not been studied in COPD small airways. The aim of this
study was to quantify IL-17A and IL-17F expression in the peripheral lung tissue of patients
with COPD compared with control subjects and to identify inflammatory cells that express IL-
17. Methods IL-17 expression was assessed using immunohistochemistry in peripheral lung
tissue (18 patients with COPD and 10 smokers and 10 nonsmokers with normal lung …
responses. IL-17 expression has not been studied in COPD small airways. The aim of this
study was to quantify IL-17A and IL-17F expression in the peripheral lung tissue of patients
with COPD compared with control subjects and to identify inflammatory cells that express IL-
17. Methods IL-17 expression was assessed using immunohistochemistry in peripheral lung
tissue (18 patients with COPD and 10 smokers and 10 nonsmokers with normal lung …