Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation
MS Parsons, L Loh, S Gooneratne, RJ Center, SJ Kent - Aids, 2014 - journals.lww.com
MS Parsons, L Loh, S Gooneratne, RJ Center, SJ Kent
Aids, 2014•journals.lww.comAntibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes
in the context of HIV exposure or infection. Antibody-dependent activation is heightened in
NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and
their major histocompatibility complex class I ligands during ontogeny. Differentiated NK
cells, defined as CD57+, also exhibit enhanced antibody-dependent responsiveness.
Although KIRs are more frequently expressed on CD57+ NK cells, the presented data …
in the context of HIV exposure or infection. Antibody-dependent activation is heightened in
NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and
their major histocompatibility complex class I ligands during ontogeny. Differentiated NK
cells, defined as CD57+, also exhibit enhanced antibody-dependent responsiveness.
Although KIRs are more frequently expressed on CD57+ NK cells, the presented data …
Abstract
Antibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes in the context of HIV exposure or infection. Antibody-dependent activation is heightened in NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and their major histocompatibility complex class I ligands during ontogeny. Differentiated NK cells, defined as CD57+, also exhibit enhanced antibody-dependent responsiveness. Although KIRs are more frequently expressed on CD57+ NK cells, the presented data suggest education and differentiation make independent contributions to NK cell anti-HIV envelope antibody-dependent activation.
Lippincott Williams & Wilkins